By Reinhard Schweitzer-Stenner
Sheds new mild on intrinsically disordered proteins and peptides, together with their function in neurodegenerative diseases
With the invention of intrinsically disordered proteins and peptides (IDPs), researchers learned that proteins don't inevitably undertake a good outlined secondary and tertiary constitution so as to practice organic features. actually, IDPs play biologically proper roles, appearing as inhibitors, scavengers, or even facilitating DNA/RNA-protein interactions. as a result of their propensity for self-aggregation and fibril formation, a few IDPs are keen on neurodegenerative ailments similar to Parkinson's and Alzheimer's.
With contributions from prime researchers, this article studies the latest reviews, encapsulating our realizing of IDPs. The authors clarify how the growing to be physique of IDP learn is construction our wisdom of the folding technique, the binding of ligands to receptor molecules, and peptide self-aggregation. Readers will find a number of experimental, theoretical, and computational techniques used to raised comprehend the homes and serve as of IDPs. furthermore, they will notice the function of IDPs in human sickness and as drug targets.
Protein and Peptide Folding, Misfolding, and Non-Folding starts with an creation that explains why examine on IDPs has considerably increased some time past few years. subsequent, the publication is split into 3 sections:
Conformational research of opened up States
Disordered Peptides and Molecular Recognition
Aggregation of Disordered Peptides
Throughout the ebook, designated figures aid readers comprehend the constitution, houses, and serve as of IDPs. References on the finish of every bankruptcy function a gateway to the growing to be physique of literature within the field.
With the e-book of Protein and Peptide Folding, Misfolding, and Non-Folding, researchers now have a unmarried position to find IDPs, their assorted organic capabilities, and the various disciplines that experience contributed to our evolving figuring out of them.
Read or Download Protein and Peptide Folding, Misfolding, and Non-Folding (Wiley Series in Protein and Peptide Science) PDF
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Additional info for Protein and Peptide Folding, Misfolding, and Non-Folding (Wiley Series in Protein and Peptide Science)
Protein and Peptide Folding, Misfolding, and Non-Folding (Wiley Series in Protein and Peptide Science) by Reinhard Schweitzer-Stenner